Lexi-Cross is a video game written by Peter Oliphant for MS-DOS and published by Interplay Productions in 1991.

Lexi-Cross presents a futuristic TV game show, with elements similar to Wheel of Fortune, Scrabble, and Battleship.

Players can choose to play as human or alien, and computer opponents are robots.

The game came with a small booklet parodying the format and style of TV Guide that served as a game manual and copy protection device.

The words eventually comprise a theme or quotation, which the player must guess to win the game.