The TX is constructed upon the front- and all-wheel drive TNGA-K platform, shared with its Toyota Grand Highlander sibling and the mid-size XU70 Highlander/Kluger.

The TX was revealed on June 8, 2023 as part of Toyota's GA-K platform dedicated to mid-size and full-size vehicles with either a front- or all-wheel drive layout configuration.

To improve performance, enhancements were made to strengthen the TX's body rigidity and minimize noise, vibration, and harshness (NVH).

[11] Welds and adhesives are featured to increase the vehicle’s joint strength and rigidity through the main framework components of the chassis.

[12] Depending on the trim level and powertrain choice, the outboard second row seats can include heating and ventilation.

Additionally, a Traffic Jam Assist is available via a subscription and is designed to monitor surrounding traffic in low-speed driving situations on limited access roads, and will allow the vehicle to autonomously move forward and brake to keep safe distance between the TX and the preceding car.

Standard features for this trim include the same front fascia as the TX 500h F Sport Performance, exclusive 22-inch wheels, all-wheel drive, Adaptive Variable Suspension, aluminum pedals and scuff plates, and F Sport interior styling.