The uprising began on 11 November 1750 after the expected new regent of Tibet, Gyurme Namgyal, was assassinated by two Qing Manchu diplomats, or ambans.

Pholhanas, the regent of Tibet, died in February 1747, during his time in office the country had enjoyed a relatively tranquil period, still, he had had discords with the Dalai Lama and news of them had reached Beijing after 1745.

[2] On 11 November 1750 the prince was back in Lhasa, and the ambans summoned him to a conference in their office, the house that had been the residence of Lha-bzang Khan the last Khoshut King of Tibet, to assassinate him.

After killing the regent, all the guards searched the place for the members of Gyurme Namgyal's entourage, but Lobsang Trashi managed to escape by jumping through a window.

[3] Immediately after the murder, the ambans sent a messenger to Minister Gashi Pandita, asking him to take over as head of the Tibetan government.

The main official of the Gelug order, Reting Rinpoche Ngawang Chokden, personally tried in vain to hold back the crowd.

Both groups were opposed to the policies of Gyurme Namgyal, and believed that challenging the Manchu superpower could only end in a military catastrophe.

Two days after the death of Gyurme Namgyal and ambans, on 13 November, the Dalai Lama appointed his minister Gashi Pandita as provisional regent.

The news of the murder of the ambans outraged the Qing Qianlong Emperor, and he decided to take swift military action.

Luciano Petech described the end of the insurgents as follows: "On January 23, 1751 Lhasa was similar to 1728, again witnessed another horrible example of Chinese justice.

[5] Manchu General Bandi sent a report to the Qing Qianlong emperor on 26 January 1751 on how he carried out the slicings and executions of the Tibetan rebels.

The Tibetan rebels dBan-rgyas (Wang-chieh), Padma-sku-rje-c'os-a['el (Pa-t'e-ma-ku-erh-chi-ch'un-p'i-lo) and Tarqan Yasor (Ta-erh-han Ya-hsün) were sliced to death for injuring the Manchu ambans with arrows, bows and fowling pieces during the Lhasa riot when they assault the building the Manchu ambans (Labdon and Fuqing) were in.

Tibetan rebelsCh'ui-mu-cha-t'e and Rab-brtan (A-la-pu-tan) were sliced to death for looting money and setting fire during the attack on the Ambans.

He ordered the live beheadings of Man-chin Te-shih-nai and rDson-dpon dBan-rgyal (Ts'eng-pen Wang-cha-lo and P'yag-mdsod-pa Lha-skyabs (Shang-cho-t'e-pa La-cha-pu) for leading the attack on the building by being the first to go to on the staircase to the next floor and setting fire and carrying the straw to fuel the fire besides killing several men on orders from the rebel leader.

The exiled Tibetans were enslaved and given as slaves to soldiers in Ching-chou (Jingzhou), K'ang-zhou (Kangzhou) and Chiang-ning (Jiangning) in the marshall-residences there.

The Tibetan rNam-rgyal-grva-ts'an college administrator (gner-adsin) and sKyor'lun Lama were tied together with Lum-pa-nas and Na-p'od-pa on 4 scaffolds (k'rims-sin) to be sliced.