Lia Addadi (Hebrew: ליה אדדי; born 1950) is a professor of structural biology at the Weizmann Institute of Science.

[1] She was elected a member of the National Academy of Sciences (NAS) in 2017 for “distinguished and continuing achievements in original research”,[2] and the American Philosophical Society (2020).

[4][5] She moved to Rehovot for her PhD supervised by Meir Lahav on the synthesis of chiral polymers at the Weizmann Institute of Science,[6][4] which she completed in 1979.

[12] Addadi identified that mollusks build their shells using hydrophobic silk gels, aspartic acid, acid-rich proteins, and an amorphous precursor.

Her inaugural year article for Proceedings of the National Academy of Sciences of the United States of America (PNAS) considered the formation of cholesterol crystals in atherosclerosis.

Addadi used stochastic optical reconstruction microscopy and soft X-ray tomography to identify the cholesterol inside cells.