Gillick has exhibited in galleries and institutions in Europe and the United States, many of which have been collaborative projects with other artists, architects, designers and writers.

Gillick was included in the 1996 exhibition Traffic, curated by Nicholas Bourriaud, which first introduced the term Relational Aesthetics.

[1] In 2002, Gillick was selected to produce artworks for the canopy, the glass facade, the kiosks, the entrance ikon, and the vitrines, of the then-recently completed Home Office building, a United Kingdom government department, at Marsham Street, London.

[citation needed] On 1 October 2010, in an open letter to the British Government's culture secretary Jeremy Hunt — co-signed by a further 27 previous Turner Prize nominees, and 19 winners—Gillick opposed any future cuts in public funding for the arts.

As Caoimhin Mac Giolla Leith of University College Dublin has said, "Gillick's practice to date has encompassed a wide range of media and activities (including sculpture, writing, architectural and graphic design, film, and music) as well as various critical and curatorial projects, his work as a whole is also marked by a fondness for diversions and distractions, tangents and evasions.

Through his own writings and the use of specific materials in his artworks, Gillick examines how the built world carries traces of social, political and economic systems.

[13] As art critic Ina Blom has said, "Artists such as Liam Gillick ... no longer address abstraction as the principle for the creation of distinct minimalist objects, but rather try to create through design spaces for open social interaction [artworks] whose actual use is to be constantly redefined within the situation of the exhibition - without necessarily producing relational-aesthetic models of community.

[19] Major solo exhibitions include Liam Gillick: Annlee You Proposes at Tate Modern, London, 2001-2002;[20] The Wood Way at Whitechapel Gallery in London 2002; Projects 79: Liam Gillick, Literally at the Museum of Modern Art, New York, 2003;[21] A short text on the possibility of creating an economy of equivalence at Palais de Tokyo, Paris, 2005; and the retrospective project Liam Gillick: Three perspectives and a short scenario 2008-2010, which toured the Kunsthalle Zürich, the Witte de With in Rotterdam, Kunstverein München, and the Museum of Contemporary Art, Chicago.

[24] In 2016, Gillick presented a solo exhibition, titled Campaign at Serralves Museum of Contemporary Art, Porto.

[26] Alongside Ingrid Schaffner, Tirdad Zolghadr and others, Gillick is a member of the Graduate Committee of the Center for Curatorial Studies and Art in Contemporary Culture at Bard College, Annandale-on-Hudson, New York.

[8] In July 2024, Gillick married independent curator Piper Marshall[32] in a ceremony on the North Fork of Long Island.