In 1988 she was recognized as the People's Artist of the USSR, then the youngest musician in the history of the Soviet Union to obtain that title.

[1][2][3] She moved with the chamber orchestra to Ingolstadt, Germany, in 1990, where over five years she conducted them in performances and recordings, playing as a soloist.

Born in Tbilisi[4] on 2 August 1946,[1] the capital of then-Soviet Georgia, Isakadze entered music school at the age of seven.

The chairman of the festival, David Oistrakh, insisted that she graduate from the Central Musical School a year early because she had been accepted in his class at the Moscow State Conservatory without having to take the entrance exam.

[6] Beginning in 1965 she played as a violin soloist with conductors such as Jiri Kout, Paavo Berglund, Vladimir Verbitsky, Jiří Bělohlávek, Valery Gergiev, Yehudi Menuhin, Eri Klas, Aleksandr Dmitriyev, Kurt Masur, Thomas Sanderling, Michail Jurowski, Jukka-Pekka Saraste, Hiroyuki Iwaki, Rudolf Kempe, Václav Neumann, Mariss Jansons, Yan Pascal Tortelier, Herbert Blomstedt, Gintaras Rinkevičius, Neeme Järvi, Dmitry Liss and Charles Dutoit.

[3][7] She played chamber music with Gustav Rivinius, Alexander Slobodyanik, Maxim Vengerov, Barbara Hendricks, Gidon Kremer, Franz Hummel, Natalia Gutman, Grigori Zhislin, Alexander Rudin, David Geringas, Frida Bauer [Wikidata], Maria Yudina, Igor Oistrakh, Dimitri Alexeev, Ivan Monighetti, Eduard Brunner, Yuri Bashmet, Alexander Kniazev, Alexei Lubimov, Justus Frantz, Arto Noras, Dmitry Sitkovetsky, Viktor Tretiakov and many others.

Its first performances took place at the Liana Isakadze Festivals of "Friends of Facebook" and "Night Serenades" in August 2011 in Batumi (Georgia).

[6] A reviewer who had admired her rendering of Vivaldi's The Four Seasons in concert, wrote that she was at the height of her power, "digging into a work with such earnestness and such devotion that the music feels at times over-sized".

[6] He noted that her approach "adds a dimension that is hard to define but attracted me with the same intensity as those Vivaldi concertos all those years ago".

2 "Quasi una sonata", with pianist Vladimir Skanavi, was included in an anniversary edition of Schnittke's music in 2020.