Liane Jakob-Rost (born 1928 in Berlin) is a German Assyriologist.
Liane Jakob-Rost studied Ancient Near Eastern languages at the University of Berlin.
In 1978 she succeeded Gerhard Rudolf Meyer [de] as director of the museum.
Jakob-Rost's research focus was the editing and publication of cuneiform sources in the museum's collection.
She gave presentations in Germany and abroad, and also participated in several overseas exhibitions.