It is bidirectional for most of its length, running between Mother Gaston Boulevard in Brooklyn in the west and Farmers Boulevard in Queens in the east.

A portion of Liberty Avenue in South Richmond Hill is known as "Little Guyana" because it runs through an Indo-Caribbean American neighborhood with mostly Indo-Guyanese and Indo-Trinidadian and Tobagonian cultures and people there.

Indian clothing stores, puja stores, roti shops, Caribbean bakeries, Hindu temples, mosques, and other Indo-Caribbean American businesses are on this portion of Liberty Avenue.

Parallel to Liberty Avenue is 101st Avenue which was renamed Little Punjab, due its similar presence of Punjabi and other South Asian cultures.

[4] Liberty Avenue is served by the following: This article relating to roads and streets in New York City is a stub.