It is bounded by Parramatta Road in the north; the boundary between Flemington and Homebush, a small part of Cooks River and Liverpool Road (Hume Highway) in the east; the Hume Highway also in the south; and Woodville Road in the west.

It includes the suburbs of Auburn, Regents Park, Potts Hill, Sefton, Chester Hill, Bass Hill and Lidcombe, as well as Flemington and a small part of Strathfield that was formerly part of Flemington.

Before the parish was proclaimed in 1835, the Liberty Plains district was in the same area.

The name had been given when the first settlers had desired a settlement midway between Parramatta and Sydney city.

In the 1851 census there were 49 houses and 270 people in the Liberty Plains parish.