The lesion can initially be red, swollen, irritated, and bleeding, similar to a hot spot (wet eczema).

The animal's incessant licking of the lesion eventually results in a thickened, firm, oval plaque, which is the granuloma.

In psychogenic cases, psychological factors should be identified and addressed, such as being left alone all day, being confined, and changes in the household.

The most common areas affected are the lower (distal) portions of their legs, such as the carpus (wrist),[2] or sometimes another part of their body such as the base of their tail.

[3] The lesion can initially be red, shiny, swollen, hairless, irritated, and bleeding, similar to a hot spot (wet eczema).

[citation needed] Lick granulomas sometimes become infected with bacteria, causing abscessed areas or fistulous tracts (furuncles).

[8] Lick granulomas are especially seen in large active dogs left alone for long periods of time.

Arthritic and mobility problems in older dogs give them more time to lick and over-groom themselves.

[13] The animal should be tested for allergies, and treated accordingly if positive (fatty acids, antihistamines, hypoallergic diet, etc.).

It is important to catch lesions early and keep the animal from licking them to then reduce inflammation and development of a habit.