Conceived by the Basel-based company Morger Partner Architekten, the building forms a unified presence with the Kunstmuseum Liechtenstein directly adjacent.

The cubic form, as well as the construction and material of the facade, reflect the common bonds of the two institutions under the aegis of a single museum.

The collection of international modern and contemporary art covers the period from the 19th century to the present; the acquisition policy focuses on 20th and 21st-century works, especially sculptures and installations.

[citation needed] The acquisition policy intentionally avoids limitations of geography, style, epoch or specific media; instead, it pursues themes of particular significance in modern and contemporary art.

[citation needed] In 2007, the Kunstmuseum Liechtenstein together with the Kunstmuseum St. Gallen and the Museum of Modern Art, Frankfurt acquired the collection of Cologne-based gallerist Rolf Ricke that includes works by Richard Artschwager, Bill Bollinger, Donald Judd, Gary Kuehn, Fabian Marcaccio, Steven Parrino, David Reed, Richard Serra, Keith Sonnier or Jessica Stockholder.

[citation needed] Past exhibitions include Gary Kuehn, Otto Freundlich, Gottfried Honegger, Leiko Ikemura,[5] Rita McBride, Paul Klee, Jochen Gerz, André Thomkins, František Kupka, Andy Warhol, Fabian Marcaccio, Alighiero Boetti, Fred Sandback, Georg Malin, Sean Scully, Matts Leiderstam, Ferdinand Nigg, Monika Sosnowska, Joseph Beuys, Thomas Schütte, Kazimir Malevich, Martin Frommelt, Matti Braun, Christian Boltanski, Gotthard Graubner, Bill Bollinger, Bojan Šarčević, Günter Fruhtrunk, Kimsooja, Ilja Taschaschnik, Latifa Echakhch, Saâdan Afif, Alexander Rodtschenko, Charlotte Moth, Georg Malin, Bertrand Lavier or Anna Kolodzieska.

The current selection includes works by Gauguin, Picasso, Léger, Beckmann, Kirchner, Klee, Kandinsky, Dubuffet, Giacometti, Graubner, Knoebel, Morellet, Sonnier, Scully and others.