In 2005, she started a foundation, Liezel's Cause, to raise money and gather basic supplies to assist the victims of Hurricane Katrina.

In singles, her greatest result in her career was reaching to the quarterfinals at the tournament in Pattaya City in 2001, where she lost to Henrieta Nagyová.

She participated in two Grand Slam singles main draws, losing to Lindsay Davenport in the second round of the 1998 French Open.

Huber has enjoyed successful women's partnerships with Magdalena Maleeva, Ai Sugiyama, Martina Navratilova, Lindsay Davenport, Cara Black, Sania Mirza, Nadia Petrova, Bethanie Mattek-Sands, María José Martínez Sánchez, and Lisa Raymond.

Huber and her Zimbabwean partner Black made up what many tennis experts regard as one of the greatest women's doubles teams in history between mid-2005.

Huber is now a major member of the United States Fed Cup team, compiling a 6–2 record in doubles play.

In the competition, Huber has played with Julie Ditty, Vania King, Bethanie Mattek-Sands, Melanie Oudin, and Sloane Stephens.

Yaroslava Shvedova Daniela Hantuchová Samantha Stosur Cara Black Marcelo Melo Nadia Petrova