The LightHouse for the Blind and Visually Impaired is a San Francisco-based nonprofit organization, and is the oldest and largest of its kind in Northern California.

"[3] In 2014, the LightHouse received a $125 million bequest from Seattle construction insurance businessman Donald Sirkin, which is arguably the most sizable donation given to a blindness organization.

[5] The LightHouse occupies the 9th-11th floors of the building, in a three-story office space designed by blind architect and former Board of Directors President Chris Downey together with Mark Cavagnero Associates.

[citation needed] Since 2017 the annual Holman Prize has been awarded "to support the emerging adventurousness and can-do spirit of blind and low vision people worldwide".

Three winners are selected each year, and receive funding of up to $25,000 for an adventurous project which need not involve foreign travel but must "take them out of their comfort zone".