[3] She completed her primary and secondary studies at the Cristo Rey de Asunción School, from which she graduated as a Bachelor of Science and Letters in 1983.

On 14 July 1998, while Samaniego was working as head of the healthcare campus of the Social Security Institute [es] (IPS), police arrested several people in connection with a cache of prescription medications seized in Asunción.

[5] About one year later, she was re-appointed as head of the pharmaceutical unit by IPS chief Darío Filártiga, who was also a political advisor to Horacio Cartes.

[4] Lilian Samaniego joined the Colorado Party on 24 March 1982, where she was very active, holding various positions as a delegate, proxy, political secretary of the governing board, and president of the women's central commission.

[11] As Senator, she was one of the main promoters in Congress of a constitutional amendment that would have allowed the President of Paraguay to run for reelection, which was seen as done at the behest of then-President Horacio Cartes, which led to the 2017 Paraguayan crisis.