Her family began playing the local honky tonks (Laylas) with her siblings, Frank, Scarlett, Amber-Dawn and McKenna Grace, as Jypsi.
[3] Mae began doing session work for Third Man Records, which led to her playing fiddle on Jack White's 2012 (Blunderbuss) and 2014 (Lazaretto) tours.
In 2013, Lillie Mae appeared in several spots in the filmed concert Another Day, Another Time: Celebrating the Music of Inside Llewyn Davis.
In this musical feature, she played both fiddle and mandolin alongside Jack White, Dominic Davis, and Fats Kaplin as part of the backing band for artists such as Willie Nelson and Merle Haggard, Taj Mahal, Steve Martin and Edie Brickell, and Ana Gabriel.
[11] It was produced by the Dave Cobb and recorded at Nashville's RCA Studio A. Lillie Mae has performed as a solo artist on both Conan and The Late Show with Stephen Colbert.