The company operates out of three locations—Nashville, Detroit, and Soho in London—with multiple entities expanding upon the offerings of a traditional record label, including multiple live music venues, vinyl pressing plant, film studio and dark room, guitar pedal and gear company, mastering studio, vinyl subscription service, and a publishing arm.

The label’s catalog has grown to over 800 releases including albums by White’s other acts, contributions from Billie Eilish, Neil Young, Sleep, Metallica, Margo Price, Coldplay, and Jay-Z, as well as many developing artists.

The label's headquarters is located in a less prosperous neighborhood which is home to the Nashville Rescue Mission, the largest homeless shelter in the city; a transitional housing and recuperation center, and an affordable healthcare clinic.

"[5] The location is organized around five dedicated sections: the record store, a "novelties lounge", the label's offices and distribution center, a live venue and bar (The Blue Room), and a darkroom/photo studio.

Other highlights include a "Wax-O-Matic machine", which makes bright red wax molds of White's Airline guitar, and a full-color photo booth.

[8] Third Man opened its first branch location at the former Willy's Overland Motorland Company in Detroit's Cass Corridor by Record Store Day's Black Friday event on November 27, 2015.

[17] In September 2021, Third Man Records opened a third retail location, live venue, and label office in London's Soho neighborhood.

[18] During the grand opening, White performed in the basement venue as well as from the balcony belonging to visual artist Damien Hirst, whose building sits at the end of the street.

The Third Man Records Vault is a "rarity-excavating"[21] quarterly subscription service that began in September 2009 as a way to release special and otherwise unreleased content.

[24] Beginning with TMR-003, a limited edition handmade batch of 100 tri-colored 7-inch vinyl, in equal parts black, yellow, and white, were produced for exclusive distribution at Third Man's Nashville location.