In 2023, Depp starred in the HBO television drama series The Idol and contributed to its soundtrack with her single "One of the Girls", which charted on the Billboard Hot 100 and surpassed 1 billion streams on Spotify.

[9] Since her birth, she has been the subject of tabloid and media reporting, including birthdays,[10][11] attendance at society events,[12] and reviews of her fashion choices.

[32] In the same year, Depp starred in A Faithful Man, directed by Louis Garrel, and co-written by Oscar winner Jean-Claude Carrière.

[39] She starred alongside her aunt Alysson Paradis in the French independent short film Quel Joli Temps Pour Jouer Ses Vingt-ans, in which she played a young woman grieving the loss of a grandfather.

[42][43] Of her performance, Owen Gleiberman of Variety wrote, "[Depp] makes her presence felt, for perhaps the first time ever, as Catherine of Valois, whose delicate worldliness matches Henry's", while Rory O'Connor of The Film Stage called it "an excellent cameo".

[44][45] In 2021, Depp appeared in the opioid epidemic crime thriller Crisis (originally titled Dreamland) alongside Gary Oldman, Armie Hammer, Evangeline Lilly and Michelle Rodriguez.

[53][54] In 2023, Depp made her television debut starring in the HBO drama series The Idol alongside Canadian singer The Weeknd.

The series premiered at the 2023 Cannes Film Festival, where it was met with highly unfavorable reception from critics for its graphic sexual content and themes.

[58] The single that Depp recorded for the series along The Weeknd and Jennie, "One of the Girls", peaked at number 51 on the Billboard Hot 100 chart[59][60] and surpassed 1 billion streams on Spotify.

[61] In 2024, Depp starred as Ellen Hutter, a young woman traumatized by the vampire Count Orlok, in Robert Eggers’ gothic horror film Nosferatu.

[65][66][67] In August 2015, she posed for iO Tillett Wright's Self-Evident Truths Project, stating she fell somewhere "on the LGBTQA spectrum".

[70][71][72] In February 2017, both she and her mother Vanessa Paradis were photographed for Our City of Angels magazine; proceeds from its sale were donated to Planned Parenthood.