[5][6] "The Central" was best known for its Tuesday jam nights where various well-known musicians such as Joe Cocker, Brian Setzer and Jeff Baxter performed and hung out along with others in the music industry.

[10] Despite the death of River Phoenix the year the venue opened, the club became and remained a hangout for Hollywood's most popular young actors and musicians.

Adam Duritz, the lead singer of Counting Crows, worked as a Viper Room bartender in late 1994 and early 1995 to escape his newfound fame.

[16] Abroad, there is also a legal brothel in Brisbane called "The Viper Room" and nightclubs boasting the name (or a similar one) in Harrogate, Sheffield, Stockholm, and Vienna.

Until February 2009, there was a nightclub with the same name in Melbourne; it was closed down due to a spate of violent incidents that included two shootings as well as license breaches and the arrest of a co-owner on drug charges.

[21] In 1997, the Viper Room was also a place of a few early solo live performances by John Frusciante at the time of his bad physical condition caused by drug abuse.

Other performers include Hot Mom, Avril Lavigne, Neurotic Outsiders (featuring Duff McKagan, Steve Jones and John Taylor), The Penfifteen Club, Keanu Reeves (who performed there with his band Dogstar in 1997), The Cult, Slash, X, Julliette and the Licks, Concrete Blonde, Green Day, Courtney Love, Hole, Joey Ramone, Tenacious D,[22] The Strokes,[23] and Cher.