[3] Born in Jerusalem to a Palestinian family,[4] Serna attended Cheltenham Girls High School in Sydney, Australia, and graduated from the University of Technology Sydney in 2009, with a Bachelor of Mathematics and Finance and a Bachelor of International Studies.
[6] In August 2010, Serna began co-presenting Letters and Numbers on SBS Television while completing honours studying part-time in mathematics with applications in biology.
[9] Serna was co-host, with actress and presenter Renee Lim and Adam Liaw (second season winner of MasterChef Australia) of the SBS cooking show Destination Flavour which was first broadcast as a 10-part series in late 2012.
[10] Serna appeared in an episode on risk for the ABC's Catalyst television program which aired in 2019.
[11] She is again a co-presenter in a celebrity version of Letters and Numbers which commenced transmission on SBS on Saturday 2 October 2021.