She met Álvaro Uribe Vélez, a 26-year Law graduate from the University of Antioquia, at the age of 23 in March 1979 by chance when she was walking with a friend in Medellín.

[4] She had dropped out of the Pontifical Bolivarian University to raise her children where she was studying literature and linguistics, but returned in 1986 and eventually graduated from it with a Bachelor of Philosophy.

17 July 1979),[6] a Political Scientist from the Pontifical Xavierian University, former model and First Runner-Up at the Miss Colombia 2002 and who is expecting their first child; and Jerónimo Alberto (b.

[9] Months prior to her husband taking office, Moreno said in an interview that she would prefer not like to use the style of First Lady, referring to it as "petulant and pink",[10] pointing out that the title has been overused in that "there are many: that of the nation, of the department, of the municipality...",[10] and stating that she would have liked to be addressed solely as "Lina María Moreno, wife of Álvaro Uribe",[10] but establishing that that did not meant she was the sounding board of Uribe.

In 2005, in an interview for El Tiempo, she told Yamid Amat that she was for the decriminalization of abortion, but still opposed to its legalization, a move that although not radical, contradicted the official position of the State and of the President.