Playing on the Oklahoma State Cowgirls golf team she won the Road Runner Invitational, and finished sixth individually in the 2003 NCAA National Championship.

In 2005, Wessberg was runner-up at the Open de España Femenino, before securing her first LET title at the 2006 Wales Ladies Championship of Europe at Machynys Peninsula G&CC.

Wessberg was a captain's pick for the 2007 European Solheim Cup team, where she defeated Cristie Kerr in the singles and recorded a 75% points win rate.

Wessberg earned her third LET title at the 2009 UNIQA Ladies Golf Open in Austria, defeating England's Laura Davies at the second sudden-death playoff hole at Golfclub Föhrenwald in Wiener Neustadt.

When she returned in 2016 she was runner-up at the Ladies Scottish Open at Dundonald Links, and finished the season 13th on the Order of Merit.

[5] Wessberg was introduced to her life partner, former professional ice-hockey player Peter Sällqvist, by Carin Koch in 2008.