Zoghby was born in Mobile, Alabama, and began her vocal studies under Elena Nikolaidi at Florida State University.
Her professional debut came in 1973 at Chicago's Grant Park Music Festival,[1] following which she made her stage debut at Houston Grand Opera as Donna Elvira in 1975;[2] thereafter she sang opera in venues around the United States, including New York City; Washington, D.C.; Dallas; Santa Fe; and New Orleans.
[1] On January 19, 1982, she made her Metropolitan Opera debut[3] in La bohème by stepping in at the last minute for Teresa Stratas as Mimì, a performance which won her many critical plaudits.
[5] Internationally, Zoghby appeared at the Glyndebourne Festival as Mimì and as Aminta in La fedeltà premiata by Joseph Haydn.
[1] During her career she also appeared in performance at the White House, and recorded a number of operas by Haydn.