The parties did not admit wrongdoing, but a settlement of the SEC charges, pending court approval, would fine Cassava $US40 million, Barbier $175,000, Burns $85,000 and Wang $50,000.

[15] In 1991, she obtained a PhD in neuroscience from University of Cambridge[15] on a thesis titled Functional interactions of limbic afferents to the striatum and mesolimbic dopamine in reward-related processes,[16] which was supervised by Barry Everitt and Trevor Robbins.

[citation needed] She teamed up again with Teresa Bell at the 1996 Summer Olympics in Atlanta, United States, and won a silver medal in the Lightweight Double Sculls.

Burns and Wang wrote that FLNA was a critical protein in enabling Abeta42's signaling through the alpha 7 nicotinic acetylcholine receptor to induce Alzheimer's disease pathology (the publication has an expression of concern).

[37] Burns and Wang published (now retracted) the binding site on FLNA and the activation of CREB by opioid receptor – Gs coupling in the same journal the next year.

[35][40] In 2017, they stated in Neurobiology of Aging (now with an expression of concern) that the FLNA in Alzheimer's disease transgenic mice and human postmortem brain tissue has an altered conformation (based on a shift in isoelectric focusing) and that PTI-125 binding to altered FLNA restores its normal shape, thereby reducing tau hyperphosphorylation, amyloid deposits and tau-containing lesions in the brains of the mice.

[44][45][46] The U.S. Securities and Exchange Commission (SEC), the U.S. National Institutes of Health (NIH), and City University of New York (CUNY) were also investigating allegations of manipulated data.

[47][48] In June 2024, Wang was indicted by the United States Department of Justice (DOJ) for fraud and charged with falsifying data on $16 million in grant applications to the NIH related to the Alzheimer's drug in development, simufilam.

"[12] The charges filed in the United States District Court for the Western District of Texas alleged that Cassava violated "antifraud provisions of the federal securities laws" and "reporting provisions of the federal securities laws" and the SEC stated in a press release that "without admitting or denying the allegations, Cassava, Barbier, and Burns ... agreed to pay civil penalties of $40 million, $175,000, and $85,000, respectively.