It runs through the city center between the Las Rosas and Cuatro Caminos stations, for a total of 20 stations (the Cuatro Caminos - La Elipa section with 60-metre platforms and the La Almudena - Las Rosas with 90-metre platforms), linked by 14.1 km of track in a narrow gauge tunnel, with a journey that lasts approximately 33 minutes.

The Banco de España, Retiro, Manuel Becerra and Ventas stations are also not accessible.

Line 2 was extended from Sol to Quevedo on 27 December 1925, and then further to Cuatro Caminos on 1 September 1929.

Later, Canal was added as an infill station between Quevedo and Cuatro Caminos to provide interchange with the extended Line 7 on 16 October 1998.

Additionally, Line 2 was extended past La Elipa to Las Rosas on 16 March 2011.