[5] From 1964 until 1966 Spiteri was deputy editor of It-Torca, and head of publications at Union Press.
[4] Spiteri worked as a research officer with the Malta Chamber of Commerce, and joined the Central Bank of Malta in 1970,[4] later serving as its deputy governor during the Mintoff years, with the nationalisation of private banks.
[5] In 1992 Spiteri contested the party leadership following the resignation of Karmenu Mifsud Bonnici, but he was defeated by Alfred Sant.
[5] In 1996, Prime Minister Alfred Sant appointed Spiteri as Finance Minister, but he resigned only five months later, in 1997, following Sant's announcement that he would remove VAT, a policy which he disagreed with, and on which he had not been consulted.
[5] In 2003, differently from the Labour Party line, he voted in favour of EU membership.