Much of LinuxSampler is free software, but commercial reuse of some, such as the back-end, is restricted.

Due to the decoupled design the sampler can be controlled with the GUI frontend(s) even from another computer, probably even running another OS like Windows or OS X. SMP and cluster support is planned for future releases.

LinuxSampler, as the name indicates, was originally conceived to run on Linux, but thanks to the abstraction of audio and MIDI drivers and platform dependent functions, the sampler was successfully ported to Windows, OS X and FreeBSD.

The Windows version of LinuxSampler can work in standalone mode providing ASIO audio output and MME MIDI input, and as a VSTi plugin providing full integration with VST sequencers.

The OS X version supports jackd audio output and CoreMIDI input.