Contemporary sources primarily consist of promotional material written by Lockyer and his supporters and also of a far less flattering account given by George Starkey, an Alchemist and rival pill maker.

[1] One advertising broadsheet, published after Lockyer's death, describes him as an "authoriz'd physician and chymist" with "at least Forty Years Experience and Practice, both in England and most Foreign Parts".

[1] Lockyer's most notable product was his eponymous pill, which his advertisements describe as: "those most excellent Pills called, Pillulae Radijs Solis Extracta BEING an universall medicine especially in all chronical and difficult Distempers".While the name implies that they contained an extract of sunbeams, the actual composition is unknown as Lockyer kept the recipe a secret.

George Starkey, published a tract called A smart scourge for a Silly Sawcy Fool, attacking Lockyer and casting doubt on the authenticity of the letter of endorsement.

He is interred in Southwark Cathedral where he has a prominent monument in the north transept featuring a large semi-recumbent figure of himself.