Lyozna (Belarusian: Лёзна, romanized: Liozna; Russian: Лиозно, romanized: Liozno; Polish: Łoźna; German: Ljesno; Yiddish: ליאזנע, romanized: Lyozne) is an urban-type settlement in Vitebsk Region, Belarus.

[2][1] It is located 45 kilometres (28 mi) east-southeast of Vitebsk,[3] close to the border with Russia by the Vitebsk–Smolensk railroad branch and highway, on the Moshna River.

[1] The first known record of the Lyozna shtetl (small town with a high Jewish population) is dated 1654.

In 1939, 711 Jews lived in the settlement, making up 17.3 percent of the population.

[4] Lyozna remained under German military occupation until 8 October 1943.