[1] Out of all the cities in the Vitebsk Oblast, Novopolotsk is the leading producer in the refining and chemical industry business.

This refinery takes crude oil from the Volga Region of Russia and generates diesel, gasoline, and kerosine, along with other technological products.

In addition to Naftan, Belarus built a large chemical plant, called "Polymir".

[5] Khimik-SKA Novopolotsk of the Belarusian Extraleague is the local pro hockey team.

Novopolotsk is twinned with:[7] Former twin towns: In March 2022, the Polish city of Płock suspended its partnership with Novopolotsk as a response to Belarusian involvement in the 2022 Russian invasion of Ukraine.