The overproduction of leukotrienes is a major cause of inflammation in asthma, allergic rhinitis, and osteoarthritis.
[1][2] Examples of 5-LOX inhibitors include the pharmaceutical drugs meclofenamate sodium, zileuton[3][4] and the natural products myxochelins/pseudochelin[5][6] as well as nordihydroguaiaretic acid (NDGA).
[7] Some chemicals found in trace amounts in food, as well as some dietary supplements, have been shown to inhibit 5-LOX; these include baicalein, caffeic acid, curcumin,[3] hyperforin and St John's wort.
[8][9][10] Acetyl-keto-beta-boswellic acid (AKBA), one of the bioactive boswellic acids found in Boswellia serrata (Indian Frankincense) has been found to inhibit 5-lipoxygenase strongly as an allosteric inhibitor.
This drug article relating to the respiratory system is a stub.