[1] Often it is associated with focal bacterial or fungal infections, and can also manifest as one of the symptoms of an internal chemical burn.
[2] In liquefactive necrosis, the affected cell is completely digested by hydrolytic enzymes, resulting in a soft, circumscribed lesion consisting of pus and the fluid remains of necrotic tissue.
Due to excitotoxicity, hypoxic death of cells within the central nervous system can result in liquefactive necrosis.
Microscopically, the cystic space contains necrotic cell debris and macrophages filled with phagocytosed material.
Neutrophils, fighting off a bacterium, will release hydrolytic enzymes which will also attack the surrounding tissues.