It is the referral hospital for the districts of Amolatar, Apac, Dokolo, Lira, Kole, and Oyam.

[1] Lira Hospital is located along Police Road, in the central business district of the city of Lira, approximately 101 kilometres (63 mi), southeast of Gulu Regional Referral Hospital, in Gulu City.

[3] Lira Regional Referral Hospital is located approximately 339 kilometres (211 mi), by road, north of Mulago National Referral Hospital, in the city of Kampala, Uganda's capital.

[1] In September 2017, the hospital commissioned an 8-apartment building to house some of the critically essential staff, so that they can quickly respond to emergencies.

Construction of the three-story building started in January 2015 and lasted 2 years and eight months, at a cost of USh1.5 billion (approx.