She is best known for portraying Diana "Diamond" Armstrong in the 1998 film The Players Club, Neesee James on the UPN/The CW sitcom All of Us from 2003 until 2007 and Keisha Greene in the VH1 romantic comedy series Single Ladies which originally aired from 2011 to 2015.

In addition to acting, McCoy has also appeared in dozens of music videos, including "Know Filter 2" by Shleah, Tugoa, T.Lee, "Download" by Lil' Kim, Changing Faces's "Same Tempo", Ginuwine's "Last Chance", Ludacris' "Number 1 Spot", Calvin Richardson's “True Love”, Sisqó's "Incomplete", Lil Jon and Ice Cube's "Roll Call", "I Don't Wanna See" and "I Really Want to Sex Your Body”, by Link, Tupac Shakur's "Toss It Up", "Never Be The Same Again" by Ghostface Killah & Carl Thomas, "Unpredictable" by Jamie Foxx, ”Ooohhhwwweee” by Master P, “Slip N' Slide” by Danny Boy, and "Are You in the Mood" by Teddy & Dru Down.

[22] Misick resigned from office in March 2009 after an investigation found "clear signs of corruption", involving the selling-off of public land to fund his own investments.

[24] McCoy has inaccurately referred to herself as the "Queen Mother" of Ghana on multiple occasions, including during a 2019 appearance on The Wendy Williams Show.

Her remarks, along with the lax and uncritical reporting of American media outlets in response, were widely mocked on Ghanaian social media,[25] with journalist Nana Aba Anamoah accusing her of "ignorance"; Anamoah further stated that the title does not exist in the country, as Ghana is a republic and not a monarchy.

[25] McCoy, at the time, stated that "To have such an honor bestowed upon me by my own African people is a testament to my hard work and character".

[25] McCoy visited Kwanyako herself in July 2021, promising to finance a vocational centre for women and a local performance troupe.