Born in Long Island, New York, Casalino expressed interest in music as a child, learning both hands on and scholastically.

[10] Over the next several years Casalino gained popularity throughout Tampa Bay and central Florida while working on a music style that incorporated jazz standards and her compositions.

She began performing more frequently at larger events[11][12][13] such as jazz festivals, fundraisers, and football and baseball games.

In 2011, she released her debut album, Introducing Lisa Casalino, which was recorded at NOLA Studios in New York City with jazz musicians Harry Allen, Nate Najar, Chuck Redd, Jon-Erik Kellso, and Rossano Sportiello.

[23][24] To support the release of her second album, I'm Old Fashioned (2014), she performed a sold-out concert at the Palladium Theater in St. Petersburg, Florida.