[1] Downing's work is innovative in its dialogue between the critical humanities and the sciences, especially psychiatry.
Her published work focuses principally on theories of sexual perversion and queer theory; the work of Michel Foucault; ethical philosophy and film; and, most recently, the cultural meanings of criminality.
Downing trained in Modern European Languages and Literatures at the Universities of London and Oxford.
She took up a Lectureship at Queen Mary, University of London in 1999, where she was promoted to Reader in 2005.
Downing received a 2009 Philip Leverhulme Prize, a prize "awarded to outstanding scholars under the age of 36 who have made a substantial contribution to their field of study, are recognised at an international level, and whose future contributions are held to be of correspondingly high promise.