[6] In the years before launching her solo mainstream career, she noted significant influence from the black LGBT community,[7] particularly in developing a stage image with adventure, quality, and beauty.

[10] Fischer then traveled as a backup singer on his tours and sang on his albums until his death, in addition to other famous musicians, including Chaka Khan, Teddy Pendergrass, and Roberta Flack.

[12] She worked as a backup vocalist during the same period for Luther Vandross for the 22 years prior to his death[13] alongside friend and collaborator Ava Cherry,[14] juggling his concert tours and those of The Rolling Stones, with whom she grew an audience playing the foil to Mick Jagger onstage.

Fischer's solo career peaked with the 1991 release of "How Can I Ease the Pain" from her album So Intense, reaching Number One on the R&B charts, and winning a Grammy Award for Best Female R&B Vocal Performance in 1992.

[19] In a 2013 article, Fischer compared back-up singing to a "tuning fork",[20] and noted she rejected the idea of dissatisfaction and the theory of always aspiring for something more while creating music and supporting other artists.

[21] In 1992, Fischer traveled to Japan to perform in the Earth Voice Concert with Lee Ritenour, Phil Perry, Bobby Caldwell, Brenda Russell, James Ingram, Michael McDonald, Anita Baker, and others.

trilogy featured Fischer in the starring role of Doris Winter, and followed the character as she assembled a company of fellow singers for a global World Peace and Harmony Tour.

She toured with Botti through 2010,[26] including appearing nightly as guest vocalist during the trumpeter's annual holiday engagement at the Blue Note Jazz Club in New York city.

The band announced a follow-up tour 14 On Fire scheduled to start in February, including dates in the Middle East, Asia, and Europe in summer 2014, and Australia in fall 2014.

[35] In 2014, Fischer re-united with many of the back-up singers in 20 Feet From Stardom including Darlene Love, Merry Clayton, and Judith Hill to sing the national anthem at the 100th Rose Bowl in Pasadena, California.

[36] In 2014, Fischer began her solo tour accompanied by her band Grand Baton,[37] performing across the United States, Canada, Europe, Asia, Australia, and New Zealand.

[51] In February 2018, Fischer's vocal performances were featured in the HBO Film presentation Notes From The Field written and produced by playwright Anna Deavere Smith.

[52] Fischer and Grand Baton partnered with The Seattle Symphony for their program Just A Kiss Away in February 2018 in which rock music anthems such as The Rolling Stones' "Gimme Shelter" were re-created orchestrally.