She was the co-founder and CEO of Global Network Navigator (GNN), the first commercial website, which was acquired by America Online (AOL).

In 1993, Gansky co-founded Global Network Navigator (GNN), the first commercial web site and portal, with Tim O'Reilly and Dale Dougherty.

[citation needed] In 1999, she co-founded Ofoto, a digital photography company, and served as chairman and CEO.

[10][5] In July 2010,[citation needed] she launched the Global Share Economy (Mesh) Directory to support the community of share-based businesses and organizations.

[9] In addition to her roles at Ofoto and Eastman Kodak, she has been an investor and advisor to companies including 11:FS,[11] Breather, Clear Cove Systems,[12] Feastly,[13] Greenbiz, Honest Buildings,[14] Instructables,[12] muse.ai,[15] Miso Tasty, OpenRov, Turo,[16] Science Exchange,[17] Scoot Networks,[18] Solar Mosaic,[19] Sunfolding, Taskrabbit, Traity,[20] Bango plc and Trove.