[1][2] Guerrero began her show business career in the 1980s as a cheerleader for the Los Angeles Rams, after which she became entertainment director for the Atlanta Falcons and New England Patriots.

[4][5] Guerrero's character, credited as "Volunteer Bimbo",[6] tells the film's villain, Penguin (Danny DeVito), that he is the coolest role model a young person could have.

Guerrero travelled to Egypt to tape the special Opening the Tombs of the Golden Mummies, and was the first female host of the San Diego Chargers magazine-style television show.

In 2011, she won the National Headliner Award for Best Investigative Report, beating Anderson Cooper for her undercover exposé on air duct cleaning scams.

Guerrero has appeared in numerous TV and film projects throughout her forty-year career, including a starring role in Aaron Spelling's Sunset Beach, guest starring on Frasier, The George Lopez Show, In the Heat of the Night, and a recurring role in TNT's television drama series Southland.

Guerrero and her then-husband, retired baseball pitcher Scott Erickson, made an independent film titled A Plumm Summer (2007).

In 2010, Guerrero hosted the first live webcast of the 82nd Academy Awards red carpet for Oscar.com, integrating viewers' questions from Facebook into celebrity interviews.

In her 2023 book, Warrior, Guerrero revealed that an unplanned pregnancy early in her relationship with Erickson ended in a miscarriage, suffered while she was on the sideline reporting for Monday Night Football.