She played supporting roles in the films The Great Santini (1979), Peggy Sue Got Married (1986) and When Harry Met Sally... (1989), and worked in the late 1970s as a writer and photojournalist for New York Rocker magazine.
[1] Persky grew up in New York City's Greenwich Village at 87 Christopher Street, a building known for notable tenants such as H.M. Koutoukas[2] and Yoko Ono.
She received the Drama-Logue and LA Weekly Theater awards (for Best Actress) for Mayo Simon's These Men, in which she starred at the Los Angeles Actors Theatre Company and for Hearts on Fire at the Odyssey.
She has acted in over two dozen films, including American Pop, The Cotton Club, Peggy Sue Got Married, The Big Easy, When Harry Met Sally..., and Coneheads.
[11] Persky's television work has included a recurring role on Private Eye as well as appearances on NYPD Blue, The X-Files, King of the Hill, E/R, The Golden Girls, and dozens more.
Her collage work has appeared in publications including the Los Angeles Times and LA Style, and it earned her an Award for Design Excellence from Print magazine.
In 2009, Persky began making appearances on The Best Show on WFMU radio program, as both a regular caller and as an in-studio special guest.