She initially gained fame as a main cast member on The Real Housewives of Beverly Hills from 2010 until 2019.

She has been a cast member and an executive producer on Bravo's Vanderpump Rules, which launched in 2013 and was the first spinoff of the Housewives show.

"[3] Vanderpump made her film debut at the age of 13, as an uncredited extra in the 1973 romantic comedy A Touch of Class.

[8] At the age of 14, she made her television debut with the role of Ursula Marsh, in the first episode of John Halifax, Gentleman, in 1974.

[9] She had small roles in various episodic television programmes throughout the 1970s, 80s, and 90s, including Silk Stalkings and Baywatch Nights.

[10] Vanderpump appears in the 1980s music videos "Poison Arrow" and "Mantrap" by the pop band ABC[11] and "(What) In The Name of Love" by the duo Naked Eyes.

[13] Vanderpump has been featured in over 100 commercials for brands including Maltesers, Lilt, Britvic 55 and Hamlet cigars.

[16] She competed in the 16th season of Dancing with the Stars, partnered with professional dancer Gleb Savchenko, debuting on 18 March 2013.

The series was hosted by Rebel Wilson, and featured Jorge Bendersky and Dr. Callie Harris as judges.

[29] In November 2014, she released Vanderpump Beverly Hills by Pop Culture Promotions, a line of homewares.

[31] In March 2019, she opened Vanderpump Cocktail Garden, her first Las Vegas venue, located in Caesars Palace.

[36] In November 2023, Vanderpump announced that her third restaurant in Las Vegas, Pinky’s at the Flamingo, is set to open in summer 2024.

[54] Vanderpump was a recipient of the Ally Leadership Award in August 2015 from Equality California, an LGBT rights organisation.

The march went from MacArthur Park to the Chinese Consulate General in Los Angeles and started a movement to end the abuse, torture and slaughter of dogs worldwide.

[56] Together with her husband Ken and their partner, John Sessa, they launched the Stop Yulin Forever campaign.

[57] Vanderpump produced a documentary, The Road To Yulin… And Beyond, in March 2018, to draw attention to the Yulin Dog Meat Festival and bring it to an end.