Wickham is best known as a producer, line producer, location producer and Director for films, TV shows, advertisements and music videos including Home Again, Girlfriends Getaway, Hero: Inspired by The Life and Times of Mr. Ulric Cross, Forward Home: The Power of The Caribbean Diaspora, The E-Zone TV Series, Lisa Wickham's E-Zone, BET Turks and Caicos Jazz Show, BET St. Lucia Jazz Show, Chef Ainsley's Caribbean Kitchen, Tobago and Trinidad Episodes, Girls Cruise, Tobago and Trinidad Episodes, Love and Hip Hop Atlanta Season 8, Trinidad Episodes.

In 1999, Wickham was invited to co-host the mid-morning live talk show Dateline on Trinidad and Tobago Television (TTT), alongside Allyson Hennessy.

By this time Wickham had launched her own television production entity making the transition to producer-director, and producing Caribbean-syndicated shows such as The E-Zone and Bon Mange as well as music videos for some of the top soca and gospel artistes in the Caribbean, including Destra Garcia, Shurwayne Winchester, Claudette Peters, Rizon and Patrice Roberts.

By 2006 The E-Zone TV Show (produced, directed and co-presented by Wickham) had been picked up by Omni 1, Canada, and BET J, in the US having already aired in 20 Caribbean territories.

The E-Zone TV Show featured the people, places and faces of the West Indian diaspora and was the first TV Show of its kind to highlight carnivals in London, Miami, Canada, New York and most of the Caribbean Islands, St. Kitts Music Festival, Dominica's World Creole Music Festival, Antigua Sailing Week, St. Maarten Heineken Regatta, among others.

Forward Home was filmed in Holland, Suriname, Canada, Guyana, Jamaica, the US, the UK, Barbados and Trinidad and Tobago.

In 2015 she also joined the producing team of HERO: The Life and Times of Mr. Ulric Cross which eventually premiered to critical acclaim in 2018.

In 2018, Wickham became the creative producer and lead host of The NOW Morning Show on national television in Trinidad and Tobago on the station TTT.

She also attended Wirschaft Universität, Vienna, Austria, Indian Institute of Management, Ahmedabad, India, Oxford University Said Business School and the London Film Academy.