Other early acting roles included playing Diane Leeds in the first season of medical drama ER, As Claire in Bad Influence (1990), counselor Maggie Burroughs in Freddy's Dead: The Final Nightmare (1991), the title role in The Nurse (1997) and a cameo as the gynaecologist in the comedy Cruel but Necessary (2005).
[8] She provided the voice for She-Hulk in the first season of The Incredible Hulk, as well as Charley Davidson in Biker Mice from Mars in the follow-up 2006 series, taking over from Leeza Miller-McGee.
She has originated many roles on stage, playing Varya in David Mamet's debut adaptation of The Cherry Orchard at the Goodman Theatre, Rita in Craig Lucas's Prelude to a Kiss and Cleo in Lyle Kessler's Robbers.
Zane has also made many guest appearances on TV shows, including Lifestories: Families in Crisis, The Outer Limits, Judging Amy, and The Division.
[10][11][12][13] The same year she performed in The Girl from Nagasaki, a film by Michel Comte based on Madame Butterfly.