Lisco is a census-designated place (CDP) in Garden County, Nebraska, United States.

[3] Lisco was laid out in 1909 when the Union Pacific Railroad was extended to that point.

[6][7] The surrounding census county division (CCD) was still called Lisco.

According to the United States Census Bureau, the Lisco CDP has a total area of 0.60 square miles (1.55 km2), all land.

There were 12.5% of families and 24.2% of the population living below the poverty line, including no under eighteens and 25.0% of those over 64.