Lisle-en-Barrois (French pronunciation: [lil ɑ̃ baʁwa], literally Lisle in Barrois) is a commune in the Meuse department in Grand Est in north-eastern France.

It is part of the Bar-le-Duc arrondissement, and is approximately 17 km (11 miles) north of Bar-le-Duc itself.

As of 2021, the population of Lisle-en-Barrois stood at just 30 residents.

Like many rural communes in France, its population has seen a gradual decline over the years due to urban migration and demographic changes.

This Meuse geographical article is a stub.