List of Billboard Hot 100 number ones of 1988

Published by Billboard magazine, the data are based collectively on each single's weekly physical sales, and airplay.

The longest running number-one single of 1988 was "Roll With It" by Steve Winwood, which obtained four weeks at the top of the chart.

George Michael's "Faith" was the best selling single of 1988 in the United States, despite most of its weeks at number one occurring in December 1987.

That year, 17 acts earned their first number one song, such as INXS, Exposé, Rick Astley, Terence Trent D'Arby, Gloria Estefan, Miami Sound Machine, Debbie Gibson, Cheap Trick, Richard Marx, Guns N' Roses, Bobby McFerrin, Def Leppard, UB40, The Escape Club, Will to Power and Poison.

An asterisk (*) by a date indicates an unpublished, "frozen" week, due to the special double issues that Billboard published in print at the end of the year for their year-end charts.