Leonardo Watch (レオナルド・ウォッチ, Reonarudo Wotchi) is a kind and humble young photographer who came to Hellsalem's Lot to help his ailing sister.
Master of the Brain Grid Blood Battle Technique (ブレングリード流血闘術, Buren Gurīdo-ryū Kettō Jutsu), which he can use to create large cross-shaped weaponry and seal away enemies.
His ultimate technique allows him to imprison the Blood Breeds, as they can not be killed due to their immortal nature, but to do so, he must learn the enemy's true name, thus requiring Leo using his powers to reveal it.
Zapp Renfro (ザップ・レンフロ, Zappu Renfuro) is a hot-blooded, womanizing Libra member and master of the Big Dipper Blood-Fighting Style (斗流血法, Hikitsuboshiryū Keppō)'s Kagutsuchi branch, which allows him to manipulate his blood into blades and explosions.
She can move at high speeds (being able to keep up with Zapp's chain of explosions from one end of the real world to deep into the alter-world) and does a large portion of Libra's reconnaissance work.
Her power is erasing her presence, which needs a link (a chain) to connect her to the world in order to counter the effect of her ability or she will cease to exist.
She is very devoted to her husband and two young sons and fights with 954 Blood Bullet Arts (954血弾格闘技, Nain Faibu Fō Buraddo Buretto Ātsu) using high-power guns that electrocute enemies.
Dog Hummer is a handsome man who had his blood replaced with the liquefied body of the serial killer and "bad boy" Deldro Brody.
Brody can materialize as a gigantic living armor that surrounds Hummer called Exocrimson (殖装甲血槌のハマー, Ekisokurimuzon), granting him immense physical strength.
The two are often kept sealed away in the deepest part of Hellsalem's Lot's largest prison but are sometimes called up to aid Libra in dire situations, due to their raw power.
Zed is trained to use the Shinatobe branch of the Big Dipper blood-fighting style, which generates tridents and threads from his blood.
His nickname Lucky Abrams (豪運のエイブラムス, Gōun no Eiburamusu) is the result of the many curses placed on him by his vampire enemies that he has made over the years.
Neyka (ニーカ, Nīka) is Patrick's ponytailed assistant, very skilled and also gluttonous, having spent an entire Libra office party just eating food.
Theodora (ゼオドラ, Zeodora) is the Queen of Hypersensitivity (過敏王, Kabin-ō), considered the hardest of the Thirteen Kings to handle.
Michella Watch (ミシェーラ・ウォッチ, Mishēra Wotchi) is Leonardo's little sister whose sight was stolen by a demon who forcibly implanted the "All Seeing Eyes" on her brother.
Because of this, he does favors to humans who win Prosfair endurance matches against him; losers give the "remainder of their lives" to him, their minds incorporated into Arlelelle's brains so as to continue playing the game against him until life's end.
It is not known if he is alien or human, as he lost most of his body during blood training, being only an arm and a barely visible face under a tattered robe and a wild boar skull.
Lieutenant Daniel Low (ダニエル・ロウ警部補, Danieru Rō Keibuho) is a police officer who requests cooperation from Libra on risky situations in exchange for not arresting the organization.
Elder (長老, Chōrō) is the ode name used by the general manager of the NY branch of the League of High Order Spirituals.