After an obscurial attack, Newt prevents the exposure of the wizarding world to American Muggle (known as No-maj) community through an obliviating potion, dispersed by his thunderbird Frank.
In Fantastic Beasts: The Crimes of Grindelwald, Newt illegally reaches Paris with Jacob in order to track and save Credence Barebone, the obscurial responsible for the New York attack.
Along with his former professor Albus Dumbledore, Newt and his team thwart Grindelwald's plans for world domination and stop him from becoming the Minister for Magic.
Porpentina Esther "Tina" Goldstein (played by Katherine Waterston) is a grounded, down-to-earth witch and demoted auror employed by MACUSA.
Tina played an instrumental role in the New York incident, helping Newt secure the creatures that escaped from his magical suitcase.
She helps Newt to clear their names after they are framed by Percival Graves - Head of the American auror office in order to keep his motives and actions secret.
In Secrets of Dumbledore, it's revealed Tina is now head of the American Auror office in New York, so she has no part in the events of this film.
Jacob Kowalski (played by Dan Fogler) is a brave First World War veteran, a genial No-Maj and a talented and creative aspiring baker.
Hoping to get out of his dead-end factory job, he accidentally takes Newt Scamander's magical suitcase menagerie when he goes to apply for a bank loan to open a bakery.
At the end of the film, Jacob has been given the money by Newt to open his bakery, but his memory of their magical adventures are erased.
He assists Newt, Lally, Theseus, Yusuf Kama, and Dumbledore in preventing Grindelwald from stealing the election of Supreme Mugwump.
Mary Lou Barebone (played by Samantha Morton) is a fanatical No-Maj campaigner against wizardry and the abusive, adoptive mother of Credence, Chastity, and Modesty.
Unaware of his origins or that he has magical powers, Credence harbours enormous rage, which turns into a dangerous Obscurus, having been tormented for years by his abusive adoptive mother.
Newt Scamander is tasked by Albus Dumbledore to find him and protect him from Grindelwald, who wishes to use Credence in his quest for power.
In the streets of Berlin, Albus comes to meet the young man and, anticipating the confrontation, takes care beforehand to tip them into a mirror dimension in order to protect the Muggles present around them.
He is touched by his suffering and his loneliness and manages to convince him that Grindelwald has fueled his hatred, and that the Dumbledore family, who were unaware of the truth until now, have never rejected him.
Modesty Barebone (played by Faith Wood-Blagrove) is a haunted young girl who is the youngest of Mary Lou's adopted children.
Leta Lestrange (played by Zoë Kravitz, by Thea Lamb as a teenager and by Tuby Wooldenfen as a child) is an emotionally damaged and confused young woman who still exerts some control over Newt, who was once, and possibly still is, in love with her.
Eulalie "Lally" Hicks (played by Jessica Williams) is a respected teacher at Ilvermorny School of Witchcraft and Wizardry.
Anton Vogel (played by Oliver Masucci) is the current Supreme Head of the International Confederation of Wizards (ICW) and Minister of Magic for Germany.
Vicência Santos (played by Maria Fernanda Cândido) is a candidate for the post of Supreme Head of the ICW and Minister of Magic for Brazil Liu Tao (played by Dave Wong) is a candidate for the post of Supreme Head of the ICW and Minister of Magic for China.