The shortest mainline Interstate Highway in Tennessee is I-55, at a length of 12.28 miles (19.76 km) in Memphis.

The longest auxiliary Interstate Highway in Tennessee is I-840, an outer southern bypass around Nashville, at a length of 77.28 miles (124.37 km).

[4] I-24 was originally planned to run between Nashville and Chattanooga; it was approved to be extended to I-57 in southern Illinois in August 1964.

[6][7][8] The first initial segment of Interstate Highway in Tennessee was a short portion of I-65 near the Alabama state line that opened on November 15, 1958.

[17] Due to citizen opposition, a short segment of I-40 in Memphis planned to pass through the city's Overton Park was never built.

[19] Since the completion of Tennessee's original Interstates, additional segments of highway in the state have been added to the system.