As well as the human cast are her seven animal companions, who reside within Littlest Pet Shop during the day, that Blythe unexpectedly gains the ability to communicate with.
After moving into an apartment in Downtown City, Blythe Baxter, a young girl, gains the ability to communicate with animals after falling in a dumbwaiter.
Blythe earns the gratitude of the Biskit twins after defending them against a bully during gym, but ends up being forced from talking to her other friends.
When Sunil assumes Blythe has gotten lost due to his own lack of faith in his psychic abilities, he enlists the help of his friends, along with larger-than-life parrot Esteban Banderas.
While Penny Ling tries to attract the attention of the boys to get them out from the dumbwaiter, Zoe and Pepper start to fight, and within their compact space, Minka's claustrophobia is triggered.
When his dance performance in front of the show's judges gets harshly rejected, he tearfully abandons Blythe into the streets, where he befriends an ensemble of street-dancing lizards.
The pets bend over backwards to appease him, but quickly lose their patience at his pampered behavior during his stay at the day camp.
Vinnie accidentally falls into a dumpster while trying to catch a fly and is transported to the dump, where he encounters a rat that helps him get back to the pet store.
Meanwhile, a Bornean orangutan called Old Bananas (Pepper's favorite comedy idol) comes to visit the day camp, but finds herself struggling to amuse him with her jokes, in order to earn his signature thumbs-up of approval.
Sunil and Vinnie hear howling noises coming from inside the pet shop, and suspect that their friends have turned into werewolves.
A few months pass since Blythe left for her summer junior program, but her dream school is not as exciting as she thought it would be when all the campus talks about is fashion.
Jasper, who finds his worried facial expression cute, takes a picture of him with his phone and edits it into an image macro.
His attention becomes the source of jealousy for Zoe, and the vanity of the Biskit twins, who produce a music video of themselves in an attempt to become viral.
After losing a ball while playing catch, Minka and Penny Ling try to retrieve it when it rolls into a natural history museum.
Now with three of the pets missing, Blythe must manage to find them all, eventually losing the rest in the process: Sunil and Vinnie in the taxidermy section, and Russell in a supply closet.
When Blythe and the pets travel to Shanghai to attend a ceremony honoring Mrs. Twombly as originator of Kung Fu Quilting, Penny Ling is reunited with family she never knew she had.
The pets are driven to madness trying to identify a hum resonating from inside the shop, while Blythe runs for class president against the Biskits.
Blythe stresses over the upcoming International Pet Fashion Expo when she is asked to do a photo shoot for Très Blasé.
Blythe and Mrs. Twombly help a friend to make a showplace out of her rundown pet hotel, in spite of Fisher Biskit's determination to close down the place.
[3] On June 4, 2015, Hasbro announced that My Little Pony executive producer Meghan McCarthy will be a story consultant for Littlest Pet Shop.
[58] When Blythe ponders about her life calling, a century and a half aged Tortoise named Speedy Shellberg comes with an answer.
When Blythe protests that her mother's name is Lauren, Roger clarifies that her nickname was Betty, although he doesn't know how that was derived.
Vinnie, Penny Ling, and Sunil join her for an upcoming Alley Cappella championship song competition as the newly formed group "There's Note Stopping Us Meow".
Russell finally figures out by fingerprinting the stolen doorknob collection that the culprit is Twombly herself, who then explains to Blythe she sold it to buy up property in the area to create the Littlest Pet Street, her dream.
Sunil tells the story of his great grandfather Dr. Sunilenstein where Nurse Minka is a hunchbacked assistant who calls him master.
The concept involves an island princess being transformed into a brunette by space aliens, with Russell being stupid and Vinnie being a mongoose-eater, which upsets Sunil, while Minka's portrayal as a klutz annoys her.
Zoe develops a crush towards her new veterinarian's German Shepherd while Blythe and Russell spend the night camping on a freezing mountain.
Blythe debuts her new pet beachwear line; Penny Ling meets a lobster eager to get her in shape; Sunil and Vinnie face off in an intense sandcastle-building contest.
roommate, McKenna Nicole compete in a fashion show, while the pets try to figure out the cause of Sugar Sprinkle's sudden grouchy behavior.
Blythe feels guilty when she unintentionally causes Whittany and Brittany to be suspended from school while Pepper goes numb while waiting for punishment from Vinnie when she accidentally breaks his lucky rock.