The minister of health, welfare and sport (Dutch: Minister van Volksgezondheid, Welzijn en Sport) is the head of the Ministry of Health, Welfare and Sport and a member of the Cabinet and the Council of Ministers.

The incumbent minister is Fleur Agema of the Party for Freedom (PVV) who has been in office since 2 July 2024.

Regularly, a state secretary is assigned to the ministry who is tasked with specific portfolios.

The current state secretaries are Vicky Maeijer of the Party for Freedom (PVV) and Vincent Karremans of the People's Party for Freedom and Democracy (VVD) who have also been in office since 2 July 2024.

In the past, there have also been ministers without portfolio assigned to the ministry.